Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC064
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-21 10:35
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment NAKOM 1+1\2+1+1\2 MADOPAR HBS 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 15 individuals with a value less than 0.56 were subsequently diagnosed with PD. That is, 35.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.56 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 30, 'TN': 26, 'TP': 12, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 24.744
timePerCircleCoV 0.270736
timePerCircleSlope 0.00466351
meanError 2.38029
tremorFreq 6.64062
tremorRelPower 51.1791
tremorGyroAmpMean 0.103265
tremorGyroAmpSlope 0.00356709
tremorGyroAmpCoV 0.57926
tremorCoordAmpMean 0.120939
tremorCoordAmpSlope 0.000306161
tremorCoordAmpCoV 0.657479
tremorAccAmpMean 0.11359
tremorAccAmpSlope 0.000267816
tremorAccAmpCoV 0.651289
tremorPcRelVar 0.758316
tremorPcX -0.989734
tremorPcY 0.142924

Circle Segment 1

Duration 16.84 s, Accuracy Estimate 3.082 (lower is better)

Circle Segment 2

Duration 33.2 s, Accuracy Estimate 2.511 (lower is better)

Circle Segment 3

Duration 16.56 s, Accuracy Estimate 2.612 (lower is better)

Circle Segment 4

Duration 32.48 s, Accuracy Estimate 1.902 (lower is better)

Circle Segment 5

Duration 24.4 s, Accuracy Estimate 2.009 (lower is better)

Circle Segment 6

Duration 26.04 s, Accuracy Estimate 2.261 (lower is better)

Circle Segment 7

Duration 30.44 s, Accuracy Estimate 1.64 (lower is better)

Circle Segment 8

Duration 21.0 s, Accuracy Estimate 2.533 (lower is better)

Circle Segment 9

Duration 16.52 s, Accuracy Estimate 2.393 (lower is better)

Circle Segment 10

Duration 29.96 s, Accuracy Estimate 2.861 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 49.2333
timePerSpiralCoV 0.281739
timePerSpiralSlope -0.139209
meanError 2.5397
tremorFreq 6.83594
tremorRelPower 61.0835
tremorGyroAmpMean 0.152719
tremorGyroAmpSlope -0.00162233
tremorGyroAmpCoV 0.577
tremorCoordAmpMean 0.152678
tremorCoordAmpSlope -0.00151285
tremorCoordAmpCoV 0.528898
tremorAccAmpMean 0.139518
tremorAccAmpSlope -0.00161422
tremorAccAmpCoV 0.520018
tremorPcRelVar 0.796259
tremorPcX -0.884555
tremorPcY -0.466435

Spiral Segment 1

Duration 64.72 s, Accuracy Estimate 2.338 (lower is better)

Spiral Segment 2

Duration 58.08 s, Accuracy Estimate 2.514 (lower is better)

Spiral Segment 3

Duration 58.04 s, Accuracy Estimate 2.486 (lower is better)

Spiral Segment 4

Duration 49.28 s, Accuracy Estimate 2.853 (lower is better)

Spiral Segment 5

Duration 29.84 s, Accuracy Estimate 2.734 (lower is better)

Spiral Segment 6

Duration 35.44 s, Accuracy Estimate 2.314 (lower is better)

Elel

eDurationMean 1.13629
eDurationStd 0.31002
eDurationStdnorm 0.272836
eDurationMedian 1.155
eDurationQuartdelta 0.535
eDurationQuartdeltanorm 0.463203
eDurationKurt 2.46553
eDurationTrenddiff 0.345
eDurationTrendratio 1.37705
eWidthMean 3.84429
eWidthStd 1.57462
eWidthStdnorm 0.409601
eWidthMedian 3.393
eWidthQuartdelta 0.78975
eWidthQuartdeltanorm 0.232759
eWidthKurt 7.73917
eWidthTrenddiff -0.117
eWidthTrendratio 0.965517
eHeightMean 8.14654
eHeightStd 2.14335
eHeightStdnorm 0.263099
eHeightMedian 7.956
eHeightQuartdelta 3.393
eHeightQuartdeltanorm 0.426471
eHeightKurt 2.04898
eHeightTrenddiff 0.702
eHeightTrendratio 1.09524
eAspectMean 0.4822
eAspectStd 0.164329
eAspectStdnorm 0.34079
eAspectMedian 0.45098
eAspectQuartdelta 0.139939
eAspectQuartdeltanorm 0.310299
eAspectKurt 4.73069
eAspectTrenddiff -0.0494505
eAspectTrendratio 0.899554
eSlantMean -0.00698102
eSlantStd 0.184819
eSlantStdnorm -26.4745
eSlantMedian -0.0169492
eSlantQuartdelta 0.229697
eSlantQuartdeltanorm -13.5521
eSlantKurt 3.02567
eSlantTrenddiff 0.115966
eRtopMean 0.649271
eRtopStd 0.12351
eRtopStdnorm 0.190228
eRtopMedian 0.652174
eRtopQuartdelta 0.151034
eRtopQuartdeltanorm 0.231586
eRtopKurt 3.04747
eRtopTrenddiff -0.00407609
eRbotMean 0.726633
eRbotStd 0.367867
eRbotStdnorm 0.506262
eRbotMedian 0.72
eRbotQuartdelta 0.446153
eRbotQuartdeltanorm 0.619657
eRbotKurt 6.30015
eRbotTrenddiff -0.256757
eRrightMean 0.776417
eRrightStd 0.168281
eRrightStdnorm 0.216741
eRrightMedian 0.803922
eRrightQuartdelta 0.097711
eRrightQuartdeltanorm 0.121543
eRrightKurt 18.7803
eRrightTrenddiff -0.012405
eRleftMean 0.456504
eRleftStd 0.163115
eRleftStdnorm 0.357313
eRleftMedian 0.466667
eRleftQuartdelta 0.202205
eRleftQuartdeltanorm 0.433297
eRleftKurt 3.65429
eRleftTrenddiff 0.0348689
lDurationMean 1.66616
lDurationStd 0.375617
lDurationStdnorm 0.225438
lDurationMedian 1.64
lDurationQuartdelta 0.42
lDurationQuartdeltanorm 0.256098
lDurationKurt 2.9665
lDurationTrenddiff 0.205
lDurationTrendratio 1.13355
lWidthMean 4.70993
lWidthStd 1.82708
lWidthStdnorm 0.387921
lWidthMedian 3.978
lWidthQuartdelta 1.872
lWidthQuartdeltanorm 0.470588
lWidthKurt 3.43337
lWidthTrenddiff -1.521
lWidthTrendratio 0.704545
lHeightMean 15.9011
lHeightStd 2.8795
lHeightStdnorm 0.181088
lHeightMedian 14.976
lHeightQuartdelta 3.9195
lHeightQuartdeltanorm 0.261719
lHeightKurt 3.47407
lHeightTrenddiff -0.468
lHeightTrendratio 0.969231
lAspectMean 0.296514
lAspectStd 0.107975
lAspectStdnorm 0.364147
lAspectMedian 0.274336
lAspectQuartdelta 0.0857832
lAspectQuartdeltanorm 0.312694
lAspectKurt 7.64668
lAspectTrenddiff -0.0644866
lAspectTrendratio 0.791367
lSlantMean 0.0206848
lSlantStd 0.142437
lSlantStdnorm 6.88606
lSlantMedian 0.0070922
lSlantQuartdelta 0.187641
lSlantQuartdeltanorm 26.4574
lSlantKurt 4.43114
lSlantTrenddiff -0.121508
lRtopMean 0.693598
lRtopStd 0.158492
lRtopStdnorm 0.228508
lRtopMedian 0.676471
lRtopQuartdelta 0.173372
lRtopQuartdeltanorm 0.256289
lRtopKurt 4.38774
lRtopTrenddiff -0.0833333
lRbotMean 0.724434
lRbotStd 0.374571
lRbotStdnorm 0.517052
lRbotMedian 0.666667
lRbotQuartdelta 0.45434
lRbotQuartdeltanorm 0.68151
lRbotKurt 7.6683
lRbotTrenddiff 0.268319
lRrightMean 0.828295
lRrightStd 0.104195
lRrightStdnorm 0.125794
lRrightMedian 0.845455
lRrightQuartdelta 0.144166
lRrightQuartdeltanorm 0.170518
lRrightKurt 2.46239
lRrightTrenddiff -0.0116215
lRleftMean 0.499256
lRleftStd 0.185162
lRleftStdnorm 0.370876
lRleftMedian 0.524823
lRleftQuartdelta 0.276604
lRleftQuartdeltanorm 0.527044
lRleftKurt 2.20778
lRleftTrenddiff 0.103233

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.80806
sumTouchScores 15.3531
meanMovementTime 1.10389
numTouches 19
undershootPercentage 10.5263
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.778806
sumTouchScores 10.1245
meanMovementTime 1.4075
numTouches 13
undershootPercentage 0
overshootPercentage 15.3846

ZigZag

numZigzags 5
timePerZigzagMean 54.176
timePerZigzagCoV 0.147607
timePerZigzagSlope 0.0862374
meanError 2.09623
tremorFreq 6.34766
tremorRelPower 42.446
tremorGyroAmpMean 0.105146
tremorGyroAmpSlope -0.00185331
tremorGyroAmpCoV 0.56592
tremorCoordAmpMean 0.0808826
tremorCoordAmpSlope -0.0029316
tremorCoordAmpCoV 0.481484
tremorAccAmpMean 0.0888898
tremorAccAmpSlope -0.0021462
tremorAccAmpCoV 0.369957
tremorPcRelVar 0.676188
tremorPcX -0.988781
tremorPcY -0.14937

ZigZag Segment 1

Duration 46.4 s, Accuracy Estimate 2.729 (lower is better)

ZigZag Segment 2

Duration 45.16 s, Accuracy Estimate 2.034 (lower is better)

ZigZag Segment 3

Duration 56.12 s, Accuracy Estimate 1.738 (lower is better)

ZigZag Segment 4

Duration 61.72 s, Accuracy Estimate 1.944 (lower is better)

ZigZag Segment 5

Duration 61.48 s, Accuracy Estimate 2.037 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 34.152
timePerZigzagCoV 0.155773
timePerZigzagSlope -0.0463809
zigzagHeightMean 65.2471
zigzagHeightCoV 0.0497333
zigzagHeightSlope 0.0232162
meanError 0.029088
tremorFreq 6.05469
tremorRelPower 35.9528
tremorGyroAmpMean 0.0564764
tremorGyroAmpSlope -0.00112521
tremorGyroAmpCoV 0.684934
tremorCoordAmpMean 0.0693434
tremorCoordAmpSlope 0.000180386
tremorCoordAmpCoV 0.594373
tremorAccAmpMean 0.0679731
tremorAccAmpSlope -0.00149158
tremorAccAmpCoV 0.642245
tremorPcRelVar 0.635132
tremorPcX -0.940037
tremorPcY -0.341072

ZigZag Offset Segment 1

Duration 33.8 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 2

Duration 35.76 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 38.92 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 37.04 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 5

Duration 25.24 s, Accuracy Estimate 0.031 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.88}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.56}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.969372023043102}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9168356163132736}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6961375023702798}